Pharmacokinetic and Pharmacodynamic Considerations in Antimalarial Dose Optimization
نویسندگان
چکیده
منابع مشابه
Pharmacokinetic and Pharmacodynamic Considerations in Antimalarial Dose Optimization
Antimalarial drugs have usually been first deployed in areas of malaria endemicity at doses which were too low, particularly for high-risk groups such as young children and pregnant women. This may accelerate the emergence and spread of resistance, thereby shortening the useful life of the drug, but it is an inevitable consequence of the current imprecise method of dose finding. An alternative ...
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in antimalarial dose optimization 2 3 NJ White 4 5 Mahidol-Oxford Tropical Medicine Research Unit, 6 Faculty of Tropical Medicine, Mahidol University, 7 Bangkok, Thailand. 8 9 Centre for Tropical Medicine, Churchill Hospital, 10 Oxford University, Oxford, United Kingdom 11 12 13 14 15 16 17 Correspondence: 18 Prof NJ White 19 Mahidol-Oxford Research Unit, 20 Faculty of Tropical Medicine, 21 Mah...
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INTroDuCTIoN Intramammary infection (mastitis) is the most common reason for the use of antimicrobials in dairy cows (Mitchell et al. 1998; Grave et al. 1999). Antimicrobials have been used to treat mastitis for more than fifty years, but consensus about the most efficient, safe, and economical treatment is still lacking. The concept of evidence-based medicine has been introduced to veterinary ...
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Bovine mastitis is a disease that affects dairy herd production, characterized by considerable economical loss due to diminished milk secretion, potential productive cow damage, increase in production costs and milk contamination. Intramammary infection (IMMI) is the most common reason for the use of antimicrobials in dairy cows. Antimicrobials (ATMs) have been used to treat mastitis for more t...
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Therapeutic drug monitoring of any pharmacologic agent should be considered when there is both significant pharmacokinetic variability and strong, clinically relevant, exposure-effect relationships. Many antifungal drugs exhibit marked variability in drug concentration as a result of inconsistent absorption, metabolism, elimination, or interaction with concomitant medications. For each of the a...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2013
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00287-13